![]() We reviewed the role of circRNAs in the generation of oxidative stress. There were no restrictions on the publication date. To this end, we used the following search terms in English: circRNA, circular RNA, non-coding RNA, oxidative stress, reactive oxygen species, ROS, free radicals, hypoxia, temperature, ionizing radiation, ultraviolet radiation, heavy metals, environmental toxins, medicine, nutrition, inflammation, and endoplasmic reticulum stress. Here, we mainly used the electronic database (PubMed) to conduct a literature review on the role of circRNAs with respect to the promotion or inhibition of the occurrence and development of oxidative-stress‒related diseases. et al., 2019 Chen et al., 2019 Yu et al., 2019 Hanan et al., 2020b Saaoud et al., 2021), indicating that circRNA may play a central role in the generation of oxidative stress, and that there is an urgent need to obtain a detailed understanding of this relationship. Increasing number of studies are reporting that circRNAs are closely related to oxidative stress ( Zhang J. Many studies have focused on the use of circRNAs as potential biomarkers for disease. These RNAs exhibit a covalently closed loop structure and do not contain the 5′ cap and 3′ poly (A) tail ( Yu et al., 2019). Most circRNAs are predominantly derived from protein-coding genes and consist of one or more exons ( Kristensen et al., 2019). With the advent of advanced sequencing technologies, thousands of circRNAs have been identified in eukaryotes. This is due to oxidative stress drives the cellular physiological regulation response to be highly complicated, it is mainly achieved through signal transduction, transcription factors (TFs), and non-coding RNAs (ncRNAs) ( Lin, 2019). However, Nrf2 cannot effectively scavenge the free radicals ( Wang X. ![]() Nrf2 protects cells from oxidative damage by inducing the expression of antioxidant and detoxification enzymes, thus activating the oxidative stress defense system in vivo ( Hybertson et al., 2011 Ryoo and Kwak, 2018). As the main regulator" of antioxidant reactions, Nrf2 regulates the expression of genes involved in oxidative stress. Studies have found that oxidative stress is caused by a variety of factors and is regulated in many ways. Persistent oxidative stress leads to the accumulation of ROS, destroying macromolecular substances, leading to DNA damage and further mutation, and induction of cancer and other diseases ( Schieber and Chandel, 2014 Pisoschi and Pop, 2015 Baek and Lee, 2016) ( Figure 1). It is a negative effect produced by free radicals in the body. Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the antioxidant capacity ( Birben et al., 2012). In this review, we described the relationship between oxidative stress and circRNAs, the circRNAs related to oxidative stress, and the role of circRNAs in promoting or inhibiting the occurrence and development of diseases associated with the oxidative stress system. Currently, the understanding of circRNAs in the mechanism of oxidative stress is limited. Over the past years, with the development of science and technology, circular RNA (circRNA) has been found to be closely associated with oxidative stress, which plays an important role in the process of oxidative stress. Oxidative stress caused by an imbalance between the production and elimination of reactive metabolites and free radicals can lead to the development of a variety of diseases. 4Department of Oncology and Hematology, Hospital (T.C.M) Affiliated to Southwest Medical University, Luzhou, China.3Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, China.2South Sichuan Institute of Translational Medicine, Luzhou, China.1Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.Yao Zhang 1,2 † Yu Chen 1,2 † Yue Wan 3 † Yueshui Zhao 1,2 Qinglian Wen 3 Xiaolong Tang 1,2 Jing Shen 1,2 Xu Wu 1,2 Mingxing Li 1,2 Xiang Li 1 Jing Li 4 Wanping Li 1* Zhangang Xiao 1,2* Fukuan Du 1,2*
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